Antidiabetic Effects of Hesperidin and Naringin in Type 2 Diabetic Rats

This study was designed to investigate the effect of hesperidin and naringin on serum glucose, blood glycosylated hemoglobin and serum insulin levels in high fat fed (HFD)/streptozotocin (STZ)-induced type 2 diabetic rats. In addition, the effect on serum lipid profile, adiponectin and resistin levels, cardiac function parameters and liver and muscle glycogen contents was assessed. Hesperidin and naringin were orally and daily administered at a dose level of 50 mg/kg b.w. for 30 days to HFD/STZ type 2 diabetic rats. Both hesperidin and naringin supplementation potentially ameliorated the elevated levels of glucose, glycosylated hemoglobin, AST, LDH and CK-MB and the lowered serum insulin level and hepatic and muscle glycogen content of insulin resistant diabetic rats. Both compounds were also found to alleviate lipid profile and serum adiponectin and resistin levels. These results showed that hesperidin and naringin have potential antihyperglycemic and antidyslipidemic efficacies as well as cardiac function improving action in HFD/STZ-induced type 2 diabetic rats.